A finding opens the next question
A biological result can show that an idea deserves closer investigation. Moving towards a treatment requires a connected body of evidence: what causes the effect, where it can be reproduced, how an intervention reaches its target, and what else it affects.
Build the evidence around a candidate
For our glioblastoma programme, an informative sequence would establish a survivor population’s role in regrowth, test a relevant vulnerability, and examine whether the effect can be separated from damage to normal neural systems.
Candidate development would then need to address practical questions such as formulation, exposure, manufacture, and the evidence required for subsequent studies. The appropriate order depends on what earlier results establish.
Different milestones mean different things
A published observation, a reproducible preclinical result, a development candidate, and an authorised clinical study each answer different questions. The path can change direction when a result reveals that an assumption was wrong or that another approach is more promising.
We intend our research record to make those decisions understandable: what was examined, what was learned, and what the result justifies doing next.