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A case worth building | A question to investigate

Build the demand case before the destination.

Constellation imagines a different relationship between medicines research, enterprise and public discovery. Its property thesis must begin with the organisations and people who would use it, then earn the scale and form of the development.

Film credits

A striking building cannot answer an occupancy question.

The V-shaped concept gives Constellation a recognisable identity. The investment case depends on a separate question: what unmet need would make a research group, small business or operator choose this destination over an existing alternative? We propose testing the mix of space, services and access before making a site commitment. The design should respond to demand and operating realities, rather than require a particular tenant story to justify an image already selected.

Find the first practical use case.

A prospective occupier might need a modest workspace, occasional access to specialist facilities or a place to collaborate near relevant expertise. Those needs have different space, cost and management implications. The initial inputs would include the organisation's requirements, time horizon, alternatives and willingness to make a meaningful commitment. General interest in a science campus should not be counted as leased demand, and an enquiry should remain distinct from an agreed commercial obligation.

Compare a new destination with existing provision.

A credible study would examine available space, shared facilities, remote collaboration and smaller adapted premises. The proposed comparator is the realistic option a potential occupier could choose now or when they need it. We would consider access, fit-out, operating charges and specialist support alongside rent. HM Treasury's Green Book provides appraisal context, while UKRI's infrastructure resources broaden the discussion beyond buildings alone (HM Treasury, n.d.; UKRI, n.d.). Neither establishes funding, demand or endorsement for Constellation.

Let the programme determine the footprint.

The concept combines research and enterprise with public discovery, workspace and offices. Each element needs a purpose, an operator and an account of how it interacts with the others. A public route should not compromise controlled scientific areas, and an impressive shared space should not create an operating burden that occupiers cannot sustain. We propose testing a smaller initial programme against the full ambition, identifying which components are essential and which should wait for stronger evidence.

A public decision brief | An illustrative example

Open the question.
Inspect the reasoning.

Choose a business question, then look beneath its claim. See what a public source supports, what depends on the local setting and what a useful next step could be.

A medicines or implementation team considering an AI-supported evidence review.

Would a quicker review make the decision better?

The interesting question is the complete piece of work: finding relevant material, checking it, correcting the draft and reaching an accountable decision.

A proposition to investigate

Less preparation. The same ability to challenge.

An evidence-review approach could be useful if it reduces avoidable preparation while preserving source access, relevant qualifications and professional checking. That is the proposed value to test. No time reduction, accuracy improvement or customer result is asserted in this example.

The proposition is constructed for this public brief. It is not a published finding about PHARMORIS.

What the next brief would contain

A decision someone
can commission.

The decision
Whether one defined review task merits an agreed evaluation.
The comparator
The team's existing complete review process, including checking and corrections.
The evidence
Representative cases, source records, reviewer decisions, complete-task effort and exceptions.
Stop or redesign
Stop or redesign if source checking weakens, errors are unacceptable or the complete task offers insufficient value.

Constructed public example | Not PHARMORIS-generated software output or a measured customer result.

Keep this example brief

Keep location optional while evidence develops.

Scotland is under consideration. Founder Varun Sharma has described visiting AMIDS and speaking with its team and developers; those conversations are context, not a site agreement. A possible 2029 funding proposal remains prospective and conditional. The first destination should be selected through demand, technical feasibility, access and delivery considerations. We would not present the concept as committed to a location or imply that public support will fill a gap in the commercial case.

Define what would unlock the next stage.

The proposed output is a demand-and-options dossier with a prioritised occupier profile, space requirements, competing provision and unresolved delivery conditions. Stronger evidence could include detailed requirements and appropriately documented commitments, subject to their actual terms. A capital partner would need to examine development, operating and demand risks together. A beautiful concept can help people understand the ambition, but should not be used as proof of construction readiness, occupancy or financial return.

Make a smaller first commitment possible.

We invite a staged development discussion that begins with discovery and feasibility rather than land acquisition or a large build. Continuation would require credible unmet demand, a workable operating model and an affordable next stage. We would stop or change the programme if existing provision meets the need better, requirements fragment beyond a viable mix or costs depend on unconfirmed funding. Constellation should grow because the first destination earns its purpose, with investment decisions made on actual evidence.

A practical first-stage brief would distinguish committed requirements from preferences: minimum usable area, essential services, timing and acceptable operating costs. Testing that brief with potential users could reveal a smaller viable starting point or show that the proposed destination needs a different purpose before further design spending is justified.

Sources and context

HM Treasury (n.d.) The Green Book. Available at: https://www.gov.uk/government/publications/the-green-book--2 (Accessed: 14 October 2026).

UKRI (n.d.) Research and innovation infrastructure. Available at: https://www.ukri.org/what-we-do/creating-world-class-research-and-innovation-infrastructure/ (Accessed: 14 October 2026).

Another useful angle.

  • Public discovery value

    Examine Constellation public discovery through audience needs, useful engagement and sustainable operation, beginning with a pilot before a permanent museum.

  • Shared infrastructure economics

    Explore a shared research capability through real usage, specialist support and operating costs, comparing new provision with access to existing infrastructure.

  • PHARMORIS buyer demand

    Examine PHARMORIS demand through a recurring medicines task, an accountable buyer and a realistic purchasing route, with evidence needed before further investment.

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